Proposed by the Bridge EngineLongevity Frontier
Can physiological regulation be given an explicit control-theoretic mapping?
Background
Feedback language is ubiquitous in physiology. Loop gains, delays and disturbance spectra are rarely measured. This asks whether an explicit mapping can be written for one well-studied regulatory system, with measurable quantities on both sides, such that control-theoretic stability results transfer with their conditions intact.
Why it is at the frontierMissing-edge candidate: both domains connect strongly to dynamical systems, weakly to each other.
Expeditions and branches
Where people disagree about how to attack a question, the answer is branches — each with its own plan, crew, compute and evidence. Branches are never merged by vote.
No expedition has formed yet. It forms when the question attracts compute and a crew.